Clinically Proven Setting Sprays for 12-Hour Makeup Lock-In
Looking for a setting spray that’s clinically proven to keep your makeup flawless for up to 12 hours? Discover the best clean, vegan, and cruelty-free setting sprays designed to lock in your look, enhance your skin, and keep you glowing all day. Below, we highlight the top setting sprays that deliver on long-lasting wear, skin-loving ingredients, and a natural finish—perfect for every skin type.
Radiance Lock Setting Mist
12-Hour Makeup Lock-In with a Natural, Glowy Finish
Radiance Lock Setting Mist is a radiance-enhancing, alcohol-free setting spray that locks in and prolongs makeup wear for up to 12 hours—without any sticky residue. This mist is clinically formulated to keep your makeup looking fresh, dewy, and luminous from morning to night.
Key Features:
- Clinically Proven 12-Hour Hold: Keeps makeup in place for all-day confidence.
- Alcohol-Free & Fragrance-Free: Gentle on all skin types, including sensitive skin.
- Vegan & Gluten-Free: Clean beauty you can trust.
- Natural Finish: Leaves skin glowy, never greasy or cakey.
Hero Ingredients:
- Pullulan & Tightenyl™: Help to lock in makeup and tighten the look of skin.
- GlowPlex™: Delivers a radiant, healthy-looking glow.
- Hyaluronic Acid & Vegetable Squalane: Hydrate and plump skin for a smooth finish.
- Eggplant Fruit Extract: Provides antioxidant protection.
“An alcohol-free, radiance-enhancing setting spray that locks in and prolongs makeup wear without feeling sticky, so skin stays glowy and your look stays put.”
How to Use:
Shake well. Hold 8–10 inches from your face and mist evenly as the last step in your makeup routine. Reapply throughout the day as needed for a fresh, hydrated look.
Available Sizes:
- 3.4 oz / 100 ml
- 1 oz / 30 ml
Skin Loyalty Natural Finish Matte Setting Spray
Superfine, Lightweight, and Long-Lasting
Skin Loyalty Natural Finish Matte Setting Spray is your go-to for a soft matte finish that keeps makeup locked in for up to 12 hours. This superfine mist not only extends makeup wear but also reduces the appearance of fine lines, pores, and skin texture.
Key Features:
- 12-Hour Makeup Lock: Keeps your look fresh from day to night.
- Alcohol-Free & Fragrance-Free: Perfect for all skin types, including dry and sensitive skin.
- Vegan & Paraben-Free: Clean, conscious beauty.
- Hydrating & Soothing: Infused with skin-loving botanicals.
Hero Ingredients:
- Cucumber Extract: Hydrates and soothes.
- Green Tea Extract: Balances and calms the skin.
- Aloe Leaf Juice: Reduces redness and irritation.
“A superfine, lightweight setting spray that locks makeup in place while reducing the appearance of fine lines, enlarged pores, or skin texture with a soft matte finish.”
How to Use:
Hold 6–8 inches from your face and mist generously before or after makeup application. Avoid contact with eyes.
Benefits:
- Hydrates and replenishes dry skin
- Balances uneven skin tone
- Reduces redness and irritation
- Keeps makeup put for up to 12 hours
Why Choose These Setting Sprays?
Both the
Radiance Lock Setting Mist and
Skin Loyalty Natural Finish Matte Setting Spray are formulated with clean, vegan ingredients and are free from alcohol, parabens, and fragrance. They are suitable for all skin types and are designed to lock in your makeup for up to 12 hours, so you can look and feel your best all day long.
Real Results, Real Confidence
“Keeps makeup looking fresh and flawless for up to 12 hours—no touch-ups needed.”
Whether you prefer a radiant glow or a soft matte finish, these clinically proven setting sprays are your secret to long-lasting, beautiful makeup.
Images

*Alt text: Woman applying setting spray to lock in makeup for 12 hours*

*Alt text: Glowing skin after using a radiance-enhancing setting mist*

*Alt text: Makeup artist using setting spray for long-lasting makeup backstage*
Frequently Asked Questions
How do I choose between a radiant and matte setting spray?
- Radiance Lock Setting Mist is ideal for those who want a dewy, glowing finish.
- Skin Loyalty Natural Finish Matte Setting Spray is perfect for those who prefer a soft matte look and want to minimize shine.
Are these setting sprays suitable for sensitive skin?
Yes! Both are alcohol-free, fragrance-free, and formulated with gentle, hydrating ingredients.
Can I use these sprays throughout the day?
Absolutely. Both can be reapplied as needed to refresh your makeup and hydrate your skin.
Experience 12-hour makeup lock-in with clean, clinically proven setting sprays—your secret to flawless, all-day beauty.